Species: C. Caffrum
Common names: Bushwillow tree
Combretum caffrum is the Eastern Cape South African Bushwillow tree.
A variety of anti-cancer compounds called combretastatins are found within the tree bark of combretum caffrum the most potent of which is combretastatin CA-4. Combretastatins bind to the protein tubulin which is essential to cytoskeletal architecture, intercellular transport, cell migration, wound healing, and mitotic spindle development for chromosome segregation and cell division. A member of the mitotic inhibitor class of anti-cancer drugs, combretastatin disrupts tumor blood vessel networks by constricting blood supply to tumours.
The bark of the Eastern Cape Bush Willow (COMBRETUM CAFFRUM) is combined with a number of other herbs, together they form a formidable anti-cancer treatment.